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Defining the host dependencies and the transcriptional landscape of RSV infection
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Defining the host dependencies and the transcriptional landscape of RSV infection
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Journal Article
Defining the host dependencies and the transcriptional landscape of RSV infection
2025
Overview
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection in infants and the elderly. Despite its substantial global health burden, RSV-targeted treatments remain unavailable for the majority of individuals. While vaccine development is underway, a detailed understanding of the host response to RSV infection and identification of required human host factors for RSV may provide insight into combatting this pathogen. Here, we utilized single-cell RNA sequencing and functional genomics to understand the host response in both RSV-infected and bystander cells, identify what host factors mediate infection, and contextualize these findings relative to dozens of previously reported screens across 17 additional viruses.
Publisher
American Society for Microbiology
Subject
/ Cells
/ CRISPR
/ Genomes
/ Genomics
/ Host-Pathogen Interactions - genetics
/ Humans
/ Respiratory Syncytial Virus Infections - genetics
/ Respiratory Syncytial Virus Infections - immunology
/ Respiratory Syncytial Virus Infections - virology
/ Respiratory Syncytial Virus, Human - genetics
/ Respiratory Syncytial Virus, Human - physiology
/ RSV
/ Severe acute respiratory syndrome coronavirus 2
/ Virology
/ Viruses
