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Investigating genetic, antigenic, and structural diversity in the Neisseria gonorrhoeae outer membrane protein, PorB: implications for vaccine design
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Investigating genetic, antigenic, and structural diversity in the Neisseria gonorrhoeae outer membrane protein, PorB: implications for vaccine design
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Journal Article
Investigating genetic, antigenic, and structural diversity in the Neisseria gonorrhoeae outer membrane protein, PorB: implications for vaccine design
2025
Overview
In the context of rising global gonorrhea cases, the development of vaccines becomes a priority; however, N. gonorrhoeae antigenic diversity and its ability to evade the immune system complicate vaccine development. This study characterizes the genetic diversity of the outer membrane protein, PorB, a key component of the outer membrane and a major gonococcal antigen. Using genomics and machine-learning techniques, this research identified dominant PorB variants that drive the immune response, proposing potential vaccine candidates and improving our understanding of the evolutionary forces maintaining genome structure and biological fitness. Understanding these processes is crucial for designing vaccines that effectively target N. gonorrhoeae and combat the spread of multidrug-resistant gonococci.
Publisher
American Society for Microbiology
Subject
/ Antigens
/ Antigens, Bacterial - genetics
/ Antigens, Bacterial - immunology
/ Bacterial Outer Membrane Proteins - genetics
/ Bacterial Outer Membrane Proteins - immunology
/ Bacterial Vaccines - genetics
/ Bacterial Vaccines - immunology
/ Epitopes
/ Genomes
/ genomics
/ Gonorrhea - prevention & control
/ Humans
/ Neisseria gonorrhoeae - classification
/ Neisseria gonorrhoeae - genetics
/ Neisseria gonorrhoeae - immunology
/ Peptides
/ Proteins
/ vaccine
/ Vaccines
