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Innate immune responses to Borrelia burgdorferi during tick-feeding: mechanistic insights relevant to Lyme disease
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Innate immune responses to Borrelia burgdorferi during tick-feeding: mechanistic insights relevant to Lyme disease
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Journal Article
Innate immune responses to Borrelia burgdorferi during tick-feeding: mechanistic insights relevant to Lyme disease
2026
Overview
Current knowledge on immune cell interactions with Borrelia burgdorferi (Bb) derives mostly from studies done in vitro and ex vivo, which cannot assess host immunity to natural tick-delivered Bb within the complex architecture of host tissues. We report the first in vivo study on local and systemic immune responses to Bb during tick feeding on a surrogate reservoir host, in comparison with uninfected-tick and subcutaneously delivered Bb. We show that uninfected-tick and tick-transmitted Bb engaged mixed type-1/type-2/type-17 immune responses in the presence of anti-inflammatory IL-10, in contrast to a type-1 response induced by subcutaneously delivered Bb. Analyses of immune responses to tick-transmitted Bb in a reservoir host can enlighten immunity mechanisms that mediate persistence of Bb.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Borrelia burgdorferi - immunology
/ Clinical Microbiology and Infectious Diseases
/ Female
/ Host Immune Responses to Zoonoses
/ Ixodes
/ Mice
/ Microbial Pathogenesis and Immunology
/ Pathogenesis and Host Response
/ tick
/ Vector-Borne Zoonotic Diseases
/ Zoonoses and Vector-Borne Diseases
