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TgJosephin and TgRad23 are important for anti-IFN-γ virulence via deubiquitination of SPM1 in Toxoplasma
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TgJosephin and TgRad23 are important for anti-IFN-γ virulence via deubiquitination of SPM1 in Toxoplasma
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TgJosephin and TgRad23 are important for anti-IFN-γ virulence via deubiquitination of SPM1 in Toxoplasma
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Journal Article
TgJosephin and TgRad23 are important for anti-IFN-γ virulence via deubiquitination of SPM1 in Toxoplasma
2026
Overview
Toxoplasma gondii is an obligate parasite whose infection can be detrimental when combined with pregnancy or immunodeficiency. Studies on T. gondii virulence have revealed various secretory proteins that inhibit the host interferon-gamma (IFN-γ) immune response. However, much of the broader virulence landscape remains unclear. To explore the unknown molecular pathways of T. gondii virulence in mice, we searched for immunosuppressive functions in genes encoding non-secretory proteins, associated with fundamental cellular processes of the virulent type I strain. Here, we found that TgJosephin, a highly conserved deubiquitinase, was important for virulence in wild-type mice but not mice lacking the IFN-γ receptor (IFNγR). In addition, TgJosephin expression was dependent on TgRad23, and loss of TgJosephin led to increased ubiquitination of a microtubule protein SPM1. Our results suggest a novel anti-IFN-γ pathway of T. gondii mediated by TgJosephin and SPM1 deubiquitination.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Animals
/ ataxin-3
/ Clinical Microbiology and Infectious Diseases
/ Female
/ IFN-γ
/ Interferon-gamma - immunology
/ Mice
/ Microbial Pathogenesis and Immunology
/ Microbial Physiology and Genetics
/ Microtubule-Associated Proteins - genetics
/ Microtubule-Associated Proteins - metabolism
/ Parasite Invasion Mechanisms
/ Protozoan Proteins - genetics
/ Protozoan Proteins - metabolism
/ Rad23
/ SPM1
/ Virulence Factors - genetics
/ Virulence Factors - metabolism
/ Zoonotic and Vector-Borne Diseases
/ Zoonotic Parasitic Infections
