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Identification of reactive Borrelia burgdorferi peptides associated with Lyme disease
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Identification of reactive Borrelia burgdorferi peptides associated with Lyme disease
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Journal Article
Identification of reactive Borrelia burgdorferi peptides associated with Lyme disease
2024
Overview
Serology is the primary method of Lyme disease diagnosis, but this approach has limitations, particularly early in disease. Currently employed antibody detection assays can be improved by the identification of alternative immunodominant epitopes and the selection of optimal diagnostic targets. We employed high-density peptide arrays that enabled precise epitope mapping for a wide range of
B. burgdorferi
antigens. In combination with machine learning, this approach facilitated the selection of serologic targets early in disease and the identification of serological indicators associated with different manifestations of Lyme disease. This study provides insights into differential antibody responses during infection and outlines a new approach for improved serologic diagnosis of Lyme disease.
Publisher
American Society for Microbiology
Subject
