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Standard mouse diets lead to differences in severity in infectious and non-infectious colitis
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Standard mouse diets lead to differences in severity in infectious and non-infectious colitis
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Journal Article
Standard mouse diets lead to differences in severity in infectious and non-infectious colitis
2025
Overview
Diet is a major modulator of the microbiota and intestinal health. This report finds that two different standard mouse diets starkly alter the severity of colitis observed in a pathogen-mediated ( Clostridioides difficile ) and non-infectious (dextran sodium sulfate) mouse colitis experimental systems. These findings in part explain study-to-study variability using these mouse systems to study disease. Since the gut microbiota plays a key role in intestinal homeostasis, diet-derived modulation of the microbiota is a promising avenue to control disease driven by intestinal inflammation and may represent a potential intervention strategy for at-risk patients.
Publisher
American Society for Microbiology
Subject
