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CD46 is a cellular receptor for species D human adenovirus
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CD46 is a cellular receptor for species D human adenovirus
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Journal Article
CD46 is a cellular receptor for species D human adenovirus
2025
Overview
Several human adenovirus species D (HAdV-D) types are currently used, or under development, as viral vectors for vaccines and gene delivery. However, the unusually broad tropism observed in many HAdV-D types limits their specificity and effectiveness as targeted vectors. Since tropism is largely governed by receptor usage, and previous studies have reported conflicting findings on receptor preferences within this species, clarifying receptor usage is essential. In this study, we systematically investigated receptor usage in 18 different HAdV-D types and identified CD46 as the primary receptor. Since CD46 is widely expressed across human tissues, our findings explain the broad cellular tropism of these viruses and provide valuable insight for the rational design and refinement of HAdV-D-based vectors.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Acids
/ Adenoviruses, Human - classification
/ Adenoviruses, Human - genetics
/ Adenoviruses, Human - physiology
/ Avidity
/ CD46
/ Cells
/ Coxsackie and Adenovirus Receptor-Like Membrane Protein - genetics
/ Coxsackie and Adenovirus Receptor-Like Membrane Protein - metabolism
/ CRISPR
/ Humans
/ Membrane Cofactor Protein - genetics
/ Membrane Cofactor Protein - metabolism
/ Proteins
/ Receptors, Virus - metabolism
/ Species
/ Tropism
/ Virology
/ Viruses
