Journal Article

NEW INSECTICIDES WITH ECDYSTEROIDAL AND JUVENILE HORMONE ACTIVITY

Dhadialla, Tarlochan S., Carlson, Glenn R., Le, Dat P.

1998

Overview

Agrochemical research over the last two decades has resulted in the discovery of chemically novel insecticides that mimic the action of the two insect growth and developmental hormones, the steroidal 20-hydroxyecdysone (20E) and the sesquiterpenoid juvenile hormone (JH). Bisacylhydrazines are non-steroidal agonists of 20E and exhibit their insecticidal activity via interaction with the ecdysteroid receptor proteins. Interestingly, two of the bisacylhydrazine (tebufenozide and RH-2485) insecticides are very selectively toxic to lepidopteran pests. These insecticides are safe to beneficial insects and have a benign ecotoxicological profile. Aromatic non-terpenoidal insecticides (fenoxycarb and pyriproxyfen) mimic the action of JHs. However, like the JHs, their exact mode of action is not well understood. These insecticides are toxic to a broad spectrum of insects during their embryonic, last larval, or reproductive stages. The insecticidal, ecotoxicological properties and the mode of action of the two groups of insecticides are reviewed in this article.

• Publisher: Annual Reviews,Annual Reviews, Inc
• Subject: adverse effects / AGONISTAS / AGONISTE / AGONISTS / Animals / Biological and medical sciences / COMPOSE ORGANOAZOTE / COMPUESTO ORGANICO DEL NITROGENO / Control / CONTROL DE INSECTOS / Ecdysteroids / ECDYSTERONE / EFECTOS SECUNDARIOS / EFFET SECONDAIRE / ESTEROIDES / FENOXICARB / FENOXYCARB / FENOXYCARBE / Forecasting / Fundamental and applied biological sciences. Psychology / HALOFENOZIDE / HORMONAS DE LA MUDA / HORMONAS JUVENILES / HORMONE DE MUE / HORMONE JUVENILE / HYDRAZINES / Hydrazines - chemistry / Hydrazines - pharmacology / INSECT CONTROL / Insecta - growth & development / INSECTICIDAL ACTION / insecticidal properties / INSECTICIDAS / INSECTICIDE / INSECTICIDES / Insecticides - chemistry / Insecticides - pharmacology / Integrated pest control / JUVENILE HORMONES / Juvenile Hormones - chemistry / Juvenile Hormones - pharmacology / LUTTE ANTIINSECTE / mechanism of action / methoxyfenozide / MODE OF ACTION / Molecular Mimicry / Molecular Structure / MOULTING HORMONES / NONSTEROIDAL ECDYSTEROID AGONISTS / NONTARGET EFFECTS / NONTARGET ORGANISMS / ORGANIC NITROGEN COMPOUNDS / Phytopathology. Animal pests. Plant and forest protection / PIRETRINAS SINTETICAS / Protozoa. Invertebrates / PYRETHRINE DE SYNTHESE / PYRIPROXYFEN / REVIEWS / RH-2485 / SIDE EFFECTS / STEROIDE / STEROIDS / Steroids - agonists / Steroids - chemistry / Steroids - pharmacology / SYNTHETIC PYRETHRINS / TEBUFENOZIDE / TOXICIDAD / TOXICITE / TOXICITY