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Lipoteichoic acid biosynthesis by Staphylococcus aureus is controlled by the MspA protein
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Lipoteichoic acid biosynthesis by Staphylococcus aureus is controlled by the MspA protein
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Journal Article
Lipoteichoic acid biosynthesis by Staphylococcus aureus is controlled by the MspA protein
2024
Overview
The S. aureus cell envelope, comprising the cytoplasmic membrane, a thick peptidoglycan layer, and the anionic polymers lipoteichoic acid and wall teichoic acids, is fundamental for bacterial growth and division, as well as being the main interface between the pathogen and the host. It has become increasingly apparent that the synthesis and turnover of cell envelope components also affect the virulence of S. aureus . In this study, we show that MspA, an effector of S. aureus virulence, contributes to the maintenance of normal levels of lipoteichoic acid in the cell wall, with implications on cell cycle and size. These findings further our understanding of the connections between envelope synthesis and pathogenicity and suggest that MspA represents a promising target for the development of future therapeutic strategies.
Publisher
American Society for Microbiology
Subject
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Enzymes
/ Gene Expression Regulation, Bacterial
/ Glycerol
/ Lipopolysaccharides - biosynthesis
/ Lipopolysaccharides - metabolism
/ LTA
/ Membrane Proteins - genetics
/ Membrane Proteins - metabolism
/ Mice
/ MspA
/ Mutation
/ Proteins
/ Staphylococcal Infections - microbiology
/ Staphylococcus aureus - genetics
/ Staphylococcus aureus - metabolism
/ Teichoic Acids - biosynthesis
