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Phage-antibiotic synergy suppresses resistance emergence of Klebsiella pneumoniae by altering the evolutionary fitness
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Phage-antibiotic synergy suppresses resistance emergence of Klebsiella pneumoniae by altering the evolutionary fitness
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Journal Article
Phage-antibiotic synergy suppresses resistance emergence of Klebsiella pneumoniae by altering the evolutionary fitness
2024
Overview
Phage-antibiotic synergy (PAS) has been recently proposed as a superior strategy for the treatment of multidrug-resistant pathogens to effectively reduce bacterial load and slow down both phage and antibiotic resistance. However, the underlying mechanisms of resistance suppression by PAS have been poorly and rarely been studied. In this study, we tried to understand how PAS suppresses the emergence of resistance using a hypervirulent Klebsiella pneumoniae (KP) strain and a novel phage H5 in combination with ceftazidime (CAZ) as a model. Our study reveals a novel mechanism by which PAS drives altered evolutionary trajectory of bacterial populations, leading to suppressed emergence of resistance. The findings advance our understanding of how PAS suppresses the emergence of resistance, and are imperative for optimizing the efficacy of phage-antibiotic therapy to further improve clinical outcomes.
Publisher
American Society for Microbiology
Subject
/ Anti-Bacterial Agents - pharmacology
/ Bacteriophages - drug effects
/ Fitness
/ hypervirulent Klebsiella pneumoniae
/ Klebsiella Infections - drug therapy
/ Klebsiella Infections - microbiology
/ Klebsiella pneumoniae - drug effects
/ Klebsiella pneumoniae - genetics
/ Klebsiella pneumoniae - virology
/ Mice
/ Phages
