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Human plasma-like medium (HPLM) induces Cryptococcus neoformans in vivo cell morphologies
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Human plasma-like medium (HPLM) induces Cryptococcus neoformans in vivo cell morphologies
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Journal Article
Human plasma-like medium (HPLM) induces Cryptococcus neoformans in vivo cell morphologies
2024
Overview
The fungal pathogen
) forms yeast cells of different sizes and morphological characteristics during infection. These features are usually not seen in standard laboratory
conditions. Here, we describe
cell morphologies when
is grown in human plasma-like medium at 37°C, 5% CO
. We observed mixed-size populations of cells less than 1 µm up to 16.8 µm in cell diameter, increased capsule size, high chitin, and DNA content in larger cells. Our findings show that serum is not required for human plasma-like medium (HPLM)-induced
cellular heterogeneity. Thus, this new method offers an opportunity to investigate factors of
that mediate pathogenesis or host-pathogen interactions in a physiologically relevant setting.IMPORTANCEWe provide a description of new
culture condition using the human plasma-like medium that supports the formation of the full range of
cell morphologies of
.
Publisher
American Society for Microbiology
Subject
/ Cells
/ Cryptococcosis - microbiology
/ Cryptococcus neoformans - cytology
/ DNA
/ HPLM
/ Humans
/ Mice
/ Plasma
/ Yeast
