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Comparison of mouse models of microbial experience reveals differences in microbial diversity and response to vaccination
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Comparison of mouse models of microbial experience reveals differences in microbial diversity and response to vaccination
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Journal Article
Comparison of mouse models of microbial experience reveals differences in microbial diversity and response to vaccination
2024
Overview
Animal models are an essential tool for evaluating clinical interventions. Unfortunately, they can often fail to accurately predict outcomes when translated into humans. This failure is due in part to a lack of natural infections experienced by most laboratory animals. To improve the mouse model, we and others have exposed laboratory mice to microbes they would experience in the wild. Although these models have been growing in popularity, these different models have not been specifically compared. Here, we directly compare how three different models of microbial experience impact the immune response to influenza vaccination. We find that these models are not the same and that the degree of microbial exposure affects the magnitude of the response to vaccination. These results provide an opportunity for the field to continue comparing and contrasting these systems to determine which models best recapitulate different aspects of the human condition.
