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The microbial metabolite urolithin A reduces Clostridioides difficile toxin expression and toxin-induced epithelial damage
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The microbial metabolite urolithin A reduces Clostridioides difficile toxin expression and toxin-induced epithelial damage
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Journal Article
The microbial metabolite urolithin A reduces Clostridioides difficile toxin expression and toxin-induced epithelial damage
2024
Overview
Therapy for Clostridioides difficile infections includes the use of antibiotics, immunosuppressors, and fecal microbiota transplantation. However, these treatments have several drawbacks, including the loss of colonization resistance, the promotion of autoimmune disorders, and the potential for unknown pathogens in donor samples. To date, the potential benefits of microbial metabolites in CDI-induced colitis have not been fully investigated. Here, we report for the first time that the microbial metabolite urolithin A has the potential to block toxin production from C. difficile and enhance gut barrier function to mitigate CDI-induced colitis.
Publisher
American Society for Microbiology
