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A locus conferring tolerance to Theileria infection in African cattle

by Cook, Elizabeth Anne Jessie , Miyunga, Antoinette Aluoch , Hassan, Musa A , Marshall, Karen , Bronsvoort, Barend M , Sitt, Tatjana , Auty, Harriet , Paxton, Edith , Perle Latre De Late , Ndambuki, Gideon , Johanneke Dinie Hemmink , Powell, Jessica , Matika, Oswald , Connelley, Timothy K , Morrison, Liam , Morrison, W Ivan , Callaby, Rebecca , Talenti, Andrea , Toye, Philip , Chepkwony, Maurine , Njeru, Regina , Poole, Elizabeth Jane , Mwaura, Stephen , Prendergast, James Gd , Wragg, David

in Bos taurus / Cattle / Chromosome 15 / East Coast fever / Genetic analysis / Genetics / Infections / Linkage analysis / Livestock / Marker-assisted selection / Parasites / Patent applications / Survival / Theileria parva

2021

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2021

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2021

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Paper

A locus conferring tolerance to Theileria infection in African cattle

Cook, Elizabeth Anne Jessie,

Miyunga, Antoinette Aluoch,

Hassan, Musa A,

Marshall, Karen,

Bronsvoort, Barend M,

Sitt, Tatjana,

Auty, Harriet,

Paxton, Edith,

Perle Latre De Late,

Ndambuki, Gideon,

Johanneke Dinie Hemmink,

Powell, Jessica,

Matika, Oswald,

Connelley, Timothy K,

Morrison, Liam,

Morrison, W Ivan,

Callaby, Rebecca,

Talenti, Andrea,

Toye, Philip,

Chepkwony, Maurine,

Njeru, Regina,

Poole, Elizabeth Jane,

Mwaura, Stephen,

Prendergast, James Gd,

Wragg, David

2021

Overview

East Coast fever, a tick-borne cattle disease caused by the Theileria parva parasite, is among the biggest natural killers of cattle in East Africa, leading to over 1 million deaths annually. Here we report on the genetic analysis of a cohort of Boran cattle demonstrating heritable tolerance to infection by T. parva (h2 = 0.65, s.e. 0.57). Through a linkage analysis we identify a 6 Mb genomic region on Bos taurus chromosome 15 that is significantly associated with survival outcome following T. parva exposure. Testing this locus in an independent cohort of animals replicates this association with survival following T. parva infection. A stop gained polymorphism in this region was found to be highly associated with survival across both related and unrelated animals, with only one of the 20 homozygote carriers (T/T) of this change succumbing to the disease in contrast to 44 out of 97 animals homozygote for the reference allele (C/C). Consequently, we present a genetic locus linked to tolerance of one of Africa's most important cattle diseases, raising the promise of marker-assisted selection for cattle that are less susceptible to infection by T. parva. Competing Interest Statement The Centre for Tropical Livestock Genetics and Health (CTLGH) has filed a patent application regarding the use of this locus in improving cattle through methods such as marker assisted breeding. Footnotes * Relative risk updated. Covariates used in fitting model on IDEAL data clarified. * https://doi.org/10.7488/ds/2985

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Publisher

Cold Spring Harbor Laboratory Press,Cold Spring Harbor Laboratory

Subject

/ Cattle