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Regarding associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults
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Regarding associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults
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Journal Article
Regarding associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults
2018
Overview
Two recent meta-analyses found positive association between egg consumption and diabetes in the US population.6 7 In the present paper, we did not find positive associations between egg consumption and CVD among patients with diabetes in the sensitivity analyses.1 We supposed that one possible mechanism might be that egg consumption elevated the level of high-density lipoprotein cholesterol (HDL-C). A recent meta-analysis reported that egg consumption was associated with increased HDL-C, as well as total cholesterol and low-density lipoprotein cholesterol (LDL-C).8 Previous studies have observed that egg consumption is associated with a greater LDL-C diameter which has less harm to vascular health, and greater HDL-C particles, which are more protective against CVD.9–11 Furthermore, this meta-analysis found that the LDL-C/HDL-C ratio, a major predictor of coronary heart disease, remained unchanged.8 Therefore, the favourable effect of HDL-C may counteract the detrimental effect of LDL-C. [...]about 14% phosphatidylcholine from egg yolk can be transformed into trimethylamine N-oxide (TMAO) through gut microbiota and liver.12 Consuming ≥2 egg yolks per day results in an increased level of TMAO in healthy individuals.12 A moderate level of egg consumption (0.76 egg per day) might not deteriorate vascular health through TMAO.
