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Zinc Salts Provide a Novel, Prolonged and Rapid Inhibition of Gastric Acid Secretion
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Zinc Salts Provide a Novel, Prolonged and Rapid Inhibition of Gastric Acid Secretion
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Journal Article
Zinc Salts Provide a Novel, Prolonged and Rapid Inhibition of Gastric Acid Secretion
2011
Overview
The overproduction of acid and the associated illnesses linked to hypersecretion have a lifetime prevalence of 25-35% in the United States. Although a variety of pharmaceutical agents have been used to reduce the production of acid, alarming new evidence questions the long-term efficacy and safety of the agents. These issues coupled with the delayed onset of action and the return of symptoms in over 60% of the patients is less than satisfactory. The purpose of this study was to determine whether administration of a zinc salt could lead to a rapid and sustained increase in gastric pH in both animals and in humans and provide a new rapid acid suppression therapy.
Intracellular pH was measured with 2',7'-bis-(2-carboxyethyl)-5-and-6-carboxy-fluorescein in both human and rat gastric glands following an acid load±a secretagogue. In a separate series of studies, whole stomach acid secretion was monitored in rats. A final study used healthy human volunteers while monitoring with a gastric pH measurement received placebo, zinc salt, or a zinc salt and proton pump inhibitor (PPI).
We demonstrate that exposure to ZnCl(2) immediately abolished secretagogue-induced acid secretion in isolated human and rat gastric glands, and in intact rat stomachs. Chronic low-dose zinc exposure effectively inhibited acid secretion in whole stomachs and isolated glands. In a randomized cross-over study in 12 volunteers, exposure to a single dose of ZnCl(2) raised intragastric pH for over 3 h, including a fast onset of effect.
Our findings demonstrate that zinc offers a novel rapid and prolonged therapy to inhibit gastric acid secretion in human and rat models.
Publisher
Nature Publishing Group,Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
Subject
/ Animals
/ Biological and medical sciences
/ Chlorides - administration & dosage
/ Chlorides - pharmacokinetics
/ Female
/ Gastroenterology. Liver. Pancreas. Abdomen
/ Humans
/ Hydrogen-Ion Concentration - drug effects
/ Male
/ Omeprazole - administration & dosage
/ Omeprazole - pharmacokinetics
/ Proton Pump Inhibitors - administration & dosage
/ Proton Pump Inhibitors - pharmacology
/ Rats
