Asset Details
Do you wish to reserve the book?
Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years
Do you wish to request the book?
Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years
2010
Overview
BackgroundPatients with non-alcoholic steatohepatitis (NASH) have increased mortality and liver-related complications. In contrast, simple steatosis is considered benign and non-progressive.ObjectiveTo investigate disease progression in patients with different degrees of non-alcoholic fatty liver disease (NAFLD) activity.DesignProspective longitudinal hospital-based cohort study.PatientsFifty-two patients (age 44±9 years) with biopsy-proven NAFLD had liver biopsies repeated at month 36.ResultsAmong 13 patients with simple steatosis at baseline, 2 (15%) had a normal liver at month 36, 3 (23%) continued to have simple steatosis, 5 (39%) developed borderline NASH and 3 (23%) developed NASH. Among 22 patients with borderline NASH at baseline, 4 (18%) had simple steatosis and 13 (59%) had borderline NASH at month 36, while 5 (23%) developed NASH. Among 17 patients with NASH at baseline, 10 (59%) continued to have NASH and 6 (35%) had borderline NASH at month 36. Only 1 (6%) patient regressed to simple steatosis. Overall, 14 (27%) patients had fibrosis progression, 25 (48%) had static disease, and 13 (25%) had fibrosis regression. Reduction in body mass index and waist circumference was independently associated with non-progressive disease activity and fibrosis. The baseline serum levels and month 36 changes in adiponectin, tumour necrosis factor α, interleukin 6 and leptin were not associated with disease progression. Serum cytokeratin-18 fragment level reflected disease activity and its change correlated with the change in NAFLD activity score (R=0.51, p<0.001).ConclusionsPatients with simple steatosis may still develop NASH and fibrosis progression. Weight reduction is associated with non-progressive disease. All patients with NAFLD should undergo periodic assessment and lifestyle modification.
Publisher
BMJ Publishing Group Ltd and British Society of Gastroenterology,BMJ Publishing Group,BMJ Publishing Group LTD
Subject
/ Adult
/ Aged
/ Biological and medical sciences
/ Biopsy
/ Exercise
/ Female
/ Gangrene
/ Gastroenterology. Liver. Pancreas. Abdomen
/ Glucose
/ Humans
/ Insulin
/ Investigative techniques, diagnostic techniques (general aspects)
/ Liver. Biliary tract. Portal circulation. Exocrine pancreas
/ Male
/ Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
/ Studies
