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Poverty, development and cardiovascular trials: More questions than answers?
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Journal Article
Poverty, development and cardiovascular trials: More questions than answers?
2015
Overview
Even within countries, there are significant variations in baseline characteristics, particularly countries as large as India. [...]considerable variations are to be expected between countries and by HDI or GNI. Investigators must take these factors into account when designing, conducting and analysing trials to enable the proper interpretation of their trial findings. 9 Predefined subgroups with regards to geographical location, poverty and development are the gold standard. 14 As suggested by Rothwell, external validity should be part of (a) further research, (b) stricter requirements for trials submitted to pharmaceutical licensing authorities, (c) guidelines on the reporting of trials and systematic reviews and (d) primary reports of trials or systematic reviews in publications. 12 An analysis of poverty and development with respect to clinical trials must mention ethical considerations of multinational trials.
Publisher
BMJ Publishing Group LTD
