Journal Article

Diagnostic accuracy of late gadolinium enhancement cardiac MRI for coronary artery disease in patients with reduced left ventricular ejection fraction

Atesler, Selin, Si-Moussi, Thiziri, Suty-Selton, Christine, Bertrand, Julien, Savon, Bertrand Champeau, Jondeau, Guillaume, Millischer, Damien, Lavie-Badie, Yoan, Bayard, Julien, Safar, Benjamin, Grigore, Diana, Vasram, Reza Rossanaly, Ou, Phalla, Mandry, Damien, Farah, Bruno, Huttin, Olivier, Nallet, Olivier, Desroche, Louis-Marie, Perrin, Romain, Corré, Jérôme, Benichou, Maxime, Boiron, Philippe, Burdet, Charles, Saib, Anis, Zannad, Noura, Pathak, Atul, Ducrocq, Gregory, Travers, Jean-Yves, Mangin, Lionel, Mesnier, Jules, Logeart, Damien, Belle, Loïc, Aubert, Raphaël, Darlington, Meryl, Darmon, Arthur, Milleron, Olivier, Alfaiate, Toni, Becker, Mathieu, Auclair, Floriane, Valla, Mathieu, Venner, Clément, Durand-Zaleski, Isabelle, Yassine, Marwan, Filippetti, Laura, Diakov, Christelle, Vappereau, Alexandra, Lallemand, Clara, Bouygues, Matthieu, Hourqueig, Marion

2025

Overview

BackgroundIdentifying significant coronary artery disease (CAD) in patients with reduced left ventricular ejection fraction (rLVEF) is essential for guiding therapeutic decisions, including medical management, device implantation and potential revascularisation. Prior studies suggested that rest cardiac MRI (CMR) with late gadolinium enhancement (LGE) could reliably detect significant CAD. We aimed to evaluate the diagnostic accuracy of rest LGE-CMR for predicting significant CAD in rLVEF patients.MethodsIn this prospective, multicentre cohort study across 10 centres, adults with new-onset rLVEF≤45% without obvious cause were included. All patients underwent rest CMR and coronary angiography. Independent, blinded committees reviewed images. Significant CAD was defined as ≥70% stenosis in major coronary arteries. Ischaemic scars were identified on CMR as subendocardial LGE. The primary outcome was the sensitivity of CMR in detecting significant CAD.ResultsAmong 380 patients (median age 63 years, 68% male), significant CAD was present in 49 (13%). CMR identified ischaemic scars in 106 (28%). The sensitivity of CMR for detecting significant CAD was 57% (95% CI: 43% to 71%), specificity 76% (95% CI: 72% to 81%), positive predictive value 26% (95% CI: 18% to 35%) and negative predictive value 92% (95% CI: 89% to 95%). A CMR-first strategy would have missed 43% of significant CAD cases, many requiring revascularisation (86% of missed cases).ConclusionsIn this large, prospective multicentre study with independent image review, rest LGE-CMR demonstrated limited sensitivity for detecting significant CAD in patients with rLVEF. Relying solely on CMR could lead to missed diagnoses and undertreatment. CMR should be integrated with other diagnostic tools to optimise care in this population.Trial registration number NCT03231189.

• Publisher: BMJ Publishing Group Ltd and British Cardiovascular Society,BMJ Publishing Group LTD
• Subject: Accuracy / Aged / Binomial distribution / Cardiomyopathy / Cardiovascular disease / Contrast Media - administration & dosage / Coronary Angiography / Coronary artery disease / Coronary Artery Disease - complications / Coronary Artery Disease - diagnosis / Coronary Artery Disease - diagnostic imaging / Coronary Artery Disease - physiopathology / Coronary vessels / Cost analysis / Ejection fraction / Female / Health Care Economics and Organizations / Heart failure / Heart Failure and Cardiomyopathies / Heart Failure, Systolic / Hospital costs / Humans / Ischemia / Magnetic Resonance Imaging / Magnetic Resonance Imaging, Cine - methods / Male / Middle Aged / Original Research / Patients / Predictive Value of Tests / Prospective Studies / Reproducibility of Results / Scars / Stroke Volume - physiology / Vein & artery diseases / Ventricular Dysfunction, Left - diagnosis / Ventricular Dysfunction, Left - diagnostic imaging / Ventricular Dysfunction, Left - physiopathology / Ventricular Function, Left