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Quantitative assessment of lens opacities with anterior segment optical coherence tomography

by Cheng, A K C , Weinreb, R N , Lam, P T-H , Pang, C P , Wong, A L , Cheung, C Y L , Lam, D S C , Leung, C K-S

in Aged / Algorithms / Anterior Eye Segment - pathology / Biological and medical sciences / Cataract - classification / Cataract - diagnosis / Cataracts / Epidemiology / FDA approval / Female / Humans / Lens diseases / Lens Nucleus, Crystalline - pathology / Male / Medical imaging / Medical sciences / Miscellaneous / Morphology / Ophthalmology / Photography / Reproducibility of Results / Software / Tomography, Optical Coherence - methods / Ultrasonic imaging

2009

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Quantitative assessment of lens opacities with anterior segment optical coherence tomography

by Cheng, A K C , Weinreb, R N , Lam, P T-H , Pang, C P , Wong, A L , Cheung, C Y L , Lam, D S C , Leung, C K-S

2009

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Quantitative assessment of lens opacities with anterior segment optical coherence tomography

by Cheng, A K C , Weinreb, R N , Lam, P T-H , Pang, C P , Wong, A L , Cheung, C Y L , Lam, D S C , Leung, C K-S

2009

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Journal Article

Quantitative assessment of lens opacities with anterior segment optical coherence tomography

Cheng, A K C,

Weinreb, R N,

Lam, P T-H,

Pang, C P,

Wong, A L,

Cheung, C Y L,

Lam, D S C,

Leung, C K-S

2009

Overview

Aim:To evaluate the reliability of lens density measurement with anterior segment optical coherence tomography (OCT) and its association with the Lens Opacity Classification System Version III (LOCS III) grading.Methods:Fifty-five eyes from 55 age-related cataract patients were included. One eye from each subject was selected at random for lens evaluation. After dilation, lens photographs were taken with a slit lamp and graded against the LOCS III standardised condition. Anterior segment OCT imaging was performed on the same eyes with a high-resolution scan. The association between the anterior segment OCT nucleus density measurement and LOCS III nuclear opalescence (NO) and nuclear colour (NC) scores was evaluated with the Spearman correlation coefficient. Anterior segment OCT measurement precision, coefficient of variation (CVw), and intraclass correlation coefficient (ICC) were calculated.Results:The mean NO and NC scores were 3.39 (SD 1.10) and 3.37 (SD 1.27), respectively. Significant correlations were found between anterior segment OCT nuclear density measurements and the LOCS III NO and NC scores (r = 0.77 and 0.60, respectively, both with p<0.001). The precision, CVw and ICC of anterior segment OCT measurement were 2.05 units, 4.55% and 0.98, respectively.Conclusion:Anterior segment OCT nucleus density measurement is reliable and correlates with the LOCS III NO and NC scores.

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Publisher

BMJ Publishing Group Ltd,BMJ Publishing Group,BMJ Publishing Group LTD

Subject

Aged

/ Algorithms

/ Anterior Eye Segment - pathology

/ Biological and medical sciences

/ Cataract - classification

/ Cataract - diagnosis

/ Cataracts