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Optic nerve sheath diameter in normal-tension glaucoma patients
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Optic nerve sheath diameter in normal-tension glaucoma patients
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Optic nerve sheath diameter in normal-tension glaucoma patients
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Journal Article
Optic nerve sheath diameter in normal-tension glaucoma patients
2012
Overview
BackgroundTo report on the optic nerve sheath diameter (ONSD) in patients with normal-tension glaucoma (NTG) compared with controls without known optic nerve (ON) or intracranial disease.MethodsIn 18 patients with NTG (mean age 64.9±8.9 years; 7 women and 11 men), CT of the orbit was performed. 17 age- and gender-matched patients without ON or intracranial disease, who underwent CT of the orbits for non-ophthalmological reasons, served as controls. The widest intraorbital ONSD in axial sections was measured using a standardised technique. Study design: unmasked. Statistical analysis was performed using an independent two-tailed t Test and the non-parametric Spearman correlation test.ResultsONSD was significantly (p<0.001) increased in NTG patients (right side: mean 7.9±0.9 mm SD; left: 8.0±1.1 mm) compared with controls (right: 6.3±0.5 mm; left: 6.1±0.6 mm). Neither the NTG nor the control group had a significant difference in ONSD between males and females or between right and left sides.ConclusionsAn increased ONSD is generally associated with increased intracranial pressure; however, ONSDs in a group of NTG patients also were significantly increased compared with controls. ON sheath compartmentation and thinning of the ON sheath are two possible explanations for an increase in the ONSD in patients with NTG.
Publisher
BMJ Publishing Group Ltd,BMJ Publishing Group,BMJ Publishing Group LTD
Subject
/ Age
/ Aged
/ Biological and medical sciences
/ Female
/ Glaucoma
/ Glaucoma and intraocular pressure
/ Glaucoma, Open-Angle - diagnostic imaging
/ Glaucoma, Open-Angle - pathology
/ Humans
/ Low Tension Glaucoma - diagnostic imaging
/ Low Tension Glaucoma - pathology
/ Male
/ Myelin Sheath - diagnostic imaging
/ Optic Disk - diagnostic imaging
/ Optic Nerve - diagnostic imaging
/ Patients
/ Pressure
/ Sheaths
/ Thinning
