Journal Article

Arterial stiffness in acute decompensated heart failure and acute kidney injury: a prospective observational cohort study protocol in a tertiary hospital setting

Appunu, Krishna, Banerjee, Prithwish, Khweir, Laith, Barber, Thomas M, Ayub, Waqar, Tran, Patrick, Joshi, Mithilesh

2025

Overview

IntroductionThe cardiovascular (circulatory) system is a closed-loop system. The dynamic interaction of the heart and vascular system plays a pivotal role in maintaining adequate cardiac output. Heart failure (HF) is commonly described as a problem of the pump, that is, mechanical myocardial failure causing poor perfusion to the body. Still, the contribution of the vasculature is often neglected. Acute decompensated heart failure (ADHF) carries a poor prognosis and is often accompanied by concomitant chronic kidney disease (CKD) and acute kidney injury (AKI), which inevitably lead to adverse outcomes. The interaction of the heart with the vasculature is conceptualised as ventricular–vascular (arterial) coupling. Arterial stiffness, a non-traditional risk factor for cardiovascular disease, can be measured non-invasively using carotid–femoral pulse wave velocity (cf-PWV). High cf-PWV values mimicking increased arterial stiffness could be a causational factor towards precipitating ADHF or AKI. This study aims to assess whether cf-PWV is higher during the hospitalisation phase of patients with HF (ADHF) and CKD (AKI in CKD) compared with stable compensated HF and stable CKD.Methods and analysisThis prospective non-randomised observational study aims to recruit 120 patients aged≥60 years. Arterial stiffness will be assessed in three groups. These groups are decompensated HF with reduced ejection fraction (n=40), decompensated HF with preserved ejection fraction (n=40) and AKI in CKD stage 3a, 3b and 4, n=40. After 4 weeks from hospital discharge, patients in a stable, compensated state will be asked to attend a follow-up clinic visit to repeat the cf-PWV measurement. The primary outcome measure is variation in cf-PWV during hospitalisation against follow-up.Ethics and disseminationEthical approval was granted in October 2021 (REC reference 21/EM/0239), recruitment started in February 2022 and the results are expected in late 2025. The findings will be published in peer-reviewed journals.Trial registration numberNCT05012722.

• Publisher: British Medical Journal Publishing Group,BMJ Publishing Group LTD,BMJ Publishing Group
• Subject: Acute Kidney Injury - complications / Acute Kidney Injury - physiopathology / Acute renal failure / Aged / Blood pressure / Cardiovascular Disease / Cardiovascular Medicine / Carotid-Femoral Pulse Wave Velocity / Circulatory system / Cohort analysis / Ejection fraction / Female / Heart failure / Heart Failure - complications / Heart Failure - physiopathology / Hospitalization / Humans / Hypertension / Hypotheses / Kidney diseases / Male / Middle Aged / Mortality / Observational Studies as Topic / Pathophysiology / Patients / Prospective Studies / Protocol / Pulse Wave Analysis / Renal Insufficiency, Chronic - complications / Renal Insufficiency, Chronic - physiopathology / Tertiary Care Centers / Vascular Stiffness - physiology / Velocity