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Prognostic value of phosphorylated STAT3 in advanced rectal cancer: a study from 104 French patients included in the EORTC 22921 trial
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Prognostic value of phosphorylated STAT3 in advanced rectal cancer: a study from 104 French patients included in the EORTC 22921 trial
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Prognostic value of phosphorylated STAT3 in advanced rectal cancer: a study from 104 French patients included in the EORTC 22921 trial
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Journal Article
Prognostic value of phosphorylated STAT3 in advanced rectal cancer: a study from 104 French patients included in the EORTC 22921 trial
2010
Overview
BackgroundSignal transducer and activator of transcription 3 (STAT3) has been implicated as an oncogene in several neoplastic diseases. However, the biological effects of STAT3 have not been extensively studied in rectal carcinogenesis.AimsTo evaluate STAT3 activation in advanced rectal cancers and its association with clinicopathological variables and prognosis.MethodsNuclear immunohistochemical expression of phosphorylated STAT3 (p-STAT3) was studied in 104 advanced rectal cancers (T3–T4). All patients were participating in the EORTC 22921 trial to assess whether preoperative chemoradiotherapy followed by postoperative chemotherapy improved overall and progression-free survival.ResultsNuclear p-STAT3 expression was detected in 37.5% of rectal cancer patients. No correlation was observed between p-STAT3 and any clinicopathological variables tested. However, patients with tumours positive for p-STAT3 had significantly improved overall survival.ConclusionThese results highlight an unexpected role for nuclear p-STAT3 expression in advanced rectal cancers and need further investigation to clarify this finding.
Publisher
BMJ Publishing Group Ltd and Association of Clinical Pathologists,BMJ Publishing Group,BMJ Publishing Group LTD
Subject
/ Aged
/ Biological and medical sciences
/ Biomarkers, Tumor - metabolism
/ Biopsy
/ Cancer
/ Combined Modality Therapy - methods
/ Female
/ France
/ Gastroenterology. Liver. Pancreas. Abdomen
/ Humans
/ Investigative techniques, diagnostic techniques (general aspects)
/ Male
/ Neoplasm Proteins - metabolism
/ Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
/ Rectal Neoplasms - metabolism
/ Rectal Neoplasms - pathology
/ STAT3
/ STAT3 Transcription Factor - metabolism
/ Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
/ Studies
/ Tumors
