Journal Article

Candidemia and candiduria in critically ill patients admitted to intensive care units in France: incidence, molecular diversity, management and outcome

d'Enfert, Christophe, CandiRea Study Group Members : C. Amrein, F. Bellenfant, A. Novara, V. Lavarde (Hôpital Européen-Georges Pompidou, Paris), M. Cornet, A. Rabbat (Hôpital Hôtel-Dieu, Paris), B. Clair, G. Loubert, E. Ronco (Hôpital Raymond-Poincaré, Garches), Hôpital Ambroise Paré, Biologie et Pathogénicité fongiques (BPF), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Necker - Enfants Malades, Aegerter, Philippe, Candirea Study Group, ., J. Charpentier, F. Lebreton, H. Yéra (Hôpital Cochin Port-Royal, Paris), M.F. Mamzer, S. Challier (Hôpital Necker, Paris), Hôpital Necker - Enfants Malades, C. Cerf, S. Bretagne (Hôpital Henri-Mondor, Créteil), J.M. Guérin, J. Mateo, J. Riahi (Hôpital Lariboisière, Paris), A. Datry, V. Leblond (Hôpital Pitié–Salpêtrière, Paris), Fagon, Jean-Yves, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Kac, Guillaume, Bougnoux, Marie-Elisabeth, Hôpital Européen Georges Pompidou (H

2008

Overview

Objective: To determine the concomitant incidence, molecular diversity, management and outcome of nosocomial candidemia and candiduria in intensive care unit (ICU) patients in France.Design: A 1-year prospective observational study in 24 adult ICUs.Patients: Two hundred and sixty-two patients with nosocomial candidemia and/or candiduria.Measurements and results: Blood and urine samples were collected when signs of sepsis were present. Antifungal susceptibility of Candida strains was determined; in addition, all blood and 72% of urine C. albicans isolates were analyzed by using multi-locus sequence type (MLST). The mean incidences of candidemia and candiduria were 6.7 and 27.4/1000 admissions, respectively. Eight percent of candiduric patients developed candidemia with the same species. The mean interval between ICU admission and candidemia was 19.0 +/- 2.9 days, and 17.2 +/- 1.1 days for candiduria. C. albicans and C. glabrata were isolated in 54.2% and 17% of blood and 66.5% and 21.6% of urine Candida-positive cultures, respectively. Fluconazole was the most frequently prescribed agent. In all candidemic patients, the prescribed curative antifungal agent was active in vitro against the responsible identified strain. Crude ICU mortality was 61.8% for candidemic and 31.3% for candiduric patients. Seventy-five percent of the patients were infected with a unique C. albicans strain; cross-transmission between seven patients was suggested in one hospital.Conclusions: Candidemia is late-onset ICU-acquired infection associated with high mortality. No difference in susceptibility and genetic background were found between blood and urine strains of Candida species.

• Publisher: Springer Verlag,CCSD,Springer-Verlag,Springer,Springer Nature B.V
• Subject: Aged / Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy / Anesthesiology / Antifungal Agents / Antifungal Agents - therapeutic use / APACHE / Biological and medical sciences / Candida / Candida - classification / Candida - isolation & purification / Candidiasis / Candidiasis - blood / Candidiasis - drug therapy / Candidiasis - epidemiology / Candidiasis - urine / Catheters / Chi-Square Distribution / Clinical death. Palliative care. Organ gift and preservation / Critical Care Medicine / Critical Illness / Cross Infection / Cross Infection - blood / Cross Infection - drug therapy / Cross Infection - epidemiology / Cross Infection - urine / Emergency Medicine / Female / France / France - epidemiology / Fungal infections / Hematology / Humans / Incidence / Intensive / Intensive care / Intensive care medicine / Intensive Care Units / Life Sciences / Male / Medical sciences / Medicine / Medicine & Public Health / Microbial Sensitivity Tests / Middle Aged / Mortality / Nosocomial infections / Original / Outcome Assessment (Health Care) / Pain Medicine / Patients / Pediatrics / Pneumology/Respiratory System / Prospective Studies / Risk Factors / Sepsis / Urine / Urogenital system
• ISBN: 0002529201000