Asset Details
Do you wish to reserve the book?
PHARMACOKINETICS OF SINGLE DOSE ORAL MELOXICAM IN BOTTLENOSE DOLPHINS (TURSIOPS TRUNCATUS)
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
PHARMACOKINETICS OF SINGLE DOSE ORAL MELOXICAM IN BOTTLENOSE DOLPHINS (TURSIOPS TRUNCATUS)
Do you wish to request the book?
PHARMACOKINETICS OF SINGLE DOSE ORAL MELOXICAM IN BOTTLENOSE DOLPHINS (TURSIOPS TRUNCATUS)
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
PHARMACOKINETICS OF SINGLE DOSE ORAL MELOXICAM IN BOTTLENOSE DOLPHINS (TURSIOPS TRUNCATUS)
2014
Overview
The objective of this study was to investigate the pharmacokinetics of meloxicam in bottlenose dolphins (Tursiops truncatus). Ten adult bottlenose dolphins were used for the study. Each animal received a single oral dose of meloxicam at 0.1 mg/kg. Two to seven serial blood samples were collected per animal, at one of fourteen time points between T = 0 and T = 240 hr. Complete blood count and serum chemistry analysis were performed prior to drug administration, as well as at the final time point for each individual. Plasma drug concentrations were determined by high-pressure liquid chromatography. No adverse hematological, biochemical or clinical changes were noted during the study period. After oral administration, a peak plasma concentration of 1.03 μg/mL was achieved at approximately 11 hr. This suggests that a single oral dose of 0.1 mg/kg provides a peak plasma level similar to what is considered therapeutic in other species. However, the elimination of meloxicam in cetaceans was slower than in other species, with an elimination half-life of almost 70 hr, and detectable drug concentrations up to 7 days. A single oral dose of 0.1 mg/kg appears safe for use in this species, but caution in repeated dosing must be used, due to the prolonged elimination, until multi-dose pharmacokinetic studies are determined.
Publisher
American Association of Zoo Veterinarians
Subject
/ adults
/ Animals
/ Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
/ Anti-Inflammatory Agents, Non-Steroidal - blood
/ Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics
/ blood
/ Bottle-Nosed Dolphin - blood
/ Dolphins
/ Dosage
/ Female
/ high performance liquid chromatography
/ Male
/ Marine
/ Thiazines - administration & dosage
/ Thiazines - pharmacokinetics
/ Thiazoles - administration & dosage
/ Thiazoles - pharmacokinetics
/ Zoos
