Asset Details
Do you wish to reserve the book?
Transplantation of cultivated autologous oral mucosal epithelial cells in patients with severe ocular surface disorders
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Transplantation of cultivated autologous oral mucosal epithelial cells in patients with severe ocular surface disorders
Do you wish to request the book?
Transplantation of cultivated autologous oral mucosal epithelial cells in patients with severe ocular surface disorders
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Transplantation of cultivated autologous oral mucosal epithelial cells in patients with severe ocular surface disorders
2004
Overview
Background/aims: To determine outcomes of transplants of cultivated autologous oral epithelial cells in patients with severe ocular surface disorders. Methods: The eyes (n = 6) of four patients with Stevens-Johnson syndrome (three eyes) or chemical burns (three eyes) were studied. Autologous oral epithelial cells, grown for 2–3 weeks on a denuded amniotic membrane carrier in the presence of 3T3 fibroblasts, were air lifted. The resultant sheet was transplanted onto the damaged eye, and acceptance of the sheet by the corneal surface was confirmed 48 hours after surgery. The success of ocular surface reconstruction, graft survival, changes in visual acuity, and postoperative complications were assessed and the quality of the cultivated oral epithelial sheet was evaluated histologically. Results: At 48 hours after transplant, the entire corneal surface of all six eyes was free of epithelial defects indicating complete survival of the transplanted oral epithelium. Visual acuity was improved in all eyes. During follow up (mean 13.8 (SD 2.9) months), the corneal surface remained stable, although all eyes manifested mild peripheral neovascularisation. Conclusions: Autologous oral epithelial cells grown on denuded amniotic membrane can be transplanted to treat severe ocular surface disorders.
Publisher
BMJ Publishing Group Ltd,BMJ,BMJ Publishing Group LTD,Copyright 2004 British Journal of Ophthalmology
Subject
/ Adult
/ Amnion
/ Biological and medical sciences
/ Biopsy
/ Clinical Science - Extended Reports
/ Diseases of cornea, anterior segment and sclera
/ EDTA
/ Epithelial Cells - transplantation
/ ethylene diamine tetra-acetic acid
/ Female
/ Humans
/ Male
/ MMC
/ ocular surface reconstruction
/ OSD
/ SJS
