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Biochemical and functional abnormalities of left and right ventricular function after ultra-endurance exercise
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Biochemical and functional abnormalities of left and right ventricular function after ultra-endurance exercise
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Biochemical and functional abnormalities of left and right ventricular function after ultra-endurance exercise
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Journal Article
Biochemical and functional abnormalities of left and right ventricular function after ultra-endurance exercise
2008
Overview
Background:There is evidence that ultra-endurance exercise causes myocardial injury. The extent and duration of these changes remains unresolved. Recent reports have speculated that structural adaptations to exercise, particularly of the right ventricle, may predispose to tachyarrhythmias and sudden cardiac death.Objective:To quantify the extent and duration of post-exercise cardiac injury with particular attention to right ventricular (RV) dysfunction.Methods:27 athletes (20 male, 7 female) were tested 1 week before, immediately after and 1 week after an ultra-endurance triathlon. Tests included cardiac troponin I (cTnI), B-type natriuretic peptide (BNP) and comprehensive echocardiographic assessment.Results:26 athletes completed the race and testing procedures. Post-race, cTnI was raised in 15 athletes (58%) and the mean value for the entire cohort increased (0.17 vs 0.49 μg/l, p<0.01). BNP rose in every athlete and the mean increased significantly (12.2 vs 42.5 ng/l, p<0.001). Left ventricular ejection fraction (LVEF) was unchanged (60.4% vs 57.5%, p = 0.09), but integrated systolic strain decreased (16.9% vs 15.1%, p<0.01). New regional wall motion abnormalities developed in seven athletes (27%) and LVEF was reduced in this subgroup (57.8% vs 45.9%, p<0.001). RV function was reduced in the entire cohort with decreases in fractional area change (0.47 vs 0.39, p<0.01) and tricuspid annular plane systolic excursion (21.8 vs 19.1 mm, p<0.01). At follow-up, all variables returned to baseline except in one athlete where RV dysfunction persisted.Conclusion:Myocardial damage occurs during intense ultra-endurance exercise and, in particular, there is a significant reduction in RV function. Almost all abnormalities resolve within 1 week.
Publisher
BMJ Publishing Group Ltd and British Cardiovascular Society,BMJ,BMJ Publishing Group LTD
Subject
/ Athletes
/ Biological and medical sciences
/ Echocardiography, Doppler, Color - methods
/ Female
/ Humans
/ Male
/ Natriuretic Peptide, Brain - blood
/ Physical Endurance - physiology
/ Studies
/ Ventricular Dysfunction, Left - blood
/ Ventricular Dysfunction, Left - diagnostic imaging
/ Ventricular Dysfunction, Left - etiology
/ Ventricular Dysfunction, Left - physiopathology
/ Ventricular Dysfunction, Right - blood
/ Ventricular Dysfunction, Right - diagnostic imaging
