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Rapid Parasite Adaptation Drives Selection for High Recombination Rates
by
Bonhoeffer, Sebastian
, Regoes, Roland R.
, Salathé, Marcel
, Kouyos, Roger D.
in
Adaptation, Biological
/ Alleles
/ Animals
/ Behavior, Animal
/ Biological adaptation
/ Coevolution
/ Ecological competition
/ Evolution
/ Evolution of sex
/ Evolution, Molecular
/ Evolutionary biology
/ Genetic research
/ Genomics
/ Genotypes
/ Host parasite relationships
/ Host-Parasite Interactions
/ host–pathogen coevolution
/ Hypotheses
/ Models, Genetic
/ Models, Statistical
/ Offspring
/ Original s
/ Parasite hosts
/ Parasites
/ Pressure
/ recombination
/ Recombination, Genetic
/ Red Queen
/ Selection, Genetic
/ Systems Biology
/ Virulence
2008
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Rapid Parasite Adaptation Drives Selection for High Recombination Rates
by
Bonhoeffer, Sebastian
, Regoes, Roland R.
, Salathé, Marcel
, Kouyos, Roger D.
in
Adaptation, Biological
/ Alleles
/ Animals
/ Behavior, Animal
/ Biological adaptation
/ Coevolution
/ Ecological competition
/ Evolution
/ Evolution of sex
/ Evolution, Molecular
/ Evolutionary biology
/ Genetic research
/ Genomics
/ Genotypes
/ Host parasite relationships
/ Host-Parasite Interactions
/ host–pathogen coevolution
/ Hypotheses
/ Models, Genetic
/ Models, Statistical
/ Offspring
/ Original s
/ Parasite hosts
/ Parasites
/ Pressure
/ recombination
/ Recombination, Genetic
/ Red Queen
/ Selection, Genetic
/ Systems Biology
/ Virulence
2008
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Do you wish to request the book?
Rapid Parasite Adaptation Drives Selection for High Recombination Rates
by
Bonhoeffer, Sebastian
, Regoes, Roland R.
, Salathé, Marcel
, Kouyos, Roger D.
in
Adaptation, Biological
/ Alleles
/ Animals
/ Behavior, Animal
/ Biological adaptation
/ Coevolution
/ Ecological competition
/ Evolution
/ Evolution of sex
/ Evolution, Molecular
/ Evolutionary biology
/ Genetic research
/ Genomics
/ Genotypes
/ Host parasite relationships
/ Host-Parasite Interactions
/ host–pathogen coevolution
/ Hypotheses
/ Models, Genetic
/ Models, Statistical
/ Offspring
/ Original s
/ Parasite hosts
/ Parasites
/ Pressure
/ recombination
/ Recombination, Genetic
/ Red Queen
/ Selection, Genetic
/ Systems Biology
/ Virulence
2008
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Rapid Parasite Adaptation Drives Selection for High Recombination Rates
Journal Article
Rapid Parasite Adaptation Drives Selection for High Recombination Rates
2008
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Overview
The Red Queen hypothesis proposes that sex is maintained through selection pressure imposed by coevolving parasites: susceptible hosts are able to escape parasite pressure by recombining their genome to create resistant offspring. However, previous theoretical studies have shown that the Red Queen typically selects against sex unless selection is strong, arguing that high rates of recombination cannot evolve when parasites are of low virulence. Here we show that under the biologically plausible assumption of a severe fitness cost for parasites that fail to infect, the Red Queen can cause selection for high recombination rates, and that the strength of virulence is largely irrelevant to the direction of selection for increased recombination rates. Strong selection on parasites and short generation times make parasites usually better adapted to their hosts than vice versa and can thus favor higher recombination rates in hosts. By demonstrating the importance of host-imposed selection on parasites, our findings resolve previously reported conflicting results.
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