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Journal Article
Against all odds: anti-IgE for intrinsic asthma?
2014
Overview
For many years, pathogenetic concepts and the results of clinical trials supported the view that anti-IgE treatment is specifically effective in allergic asthma. However, there is now growing clinical and mechanistic evidence suggesting that treatment with the anti-IgE antibody omalizumab can be effective in patients with intrinsic asthma. Therefore, large and well-controlled clinical trials with anti-IgE are urgently warranted in patients with intrinsic asthma. In addition, there is a need to find new biomarkers which can identify patients with asthma who respond to anti-IgE treatment.
Publisher
BMJ Publishing Group LTD,BMJ Publishing Group
Subject
/ Anti-Asthmatic Agents - pharmacology
/ Anti-Asthmatic Agents - therapeutic use
/ Antibodies, Anti-Idiotypic - pharmacology
/ Antibodies, Anti-Idiotypic - therapeutic use
/ Antibodies, Monoclonal, Humanized - pharmacology
/ Antibodies, Monoclonal, Humanized - therapeutic use
/ Asthma
/ Humans
/ Immunity, Innate - drug effects
/ Patients
/ Skin
