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DNA Repair Proteins Affect the Lifecycle of Herpes Simplex Virus 1
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DNA Repair Proteins Affect the Lifecycle of Herpes Simplex Virus 1
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Journal Article
DNA Repair Proteins Affect the Lifecycle of Herpes Simplex Virus 1
2005
Overview
We report that herpes simplex virus 1 (HSV-1) infection can activate and exploit a cellular DNA damage response that aids viral replication in nonneuronal cells. Early in HSV-1 infection, several members of the cellular DNA damage-sensing machinery are activated and accumulate at sites of viral DNA replication. When this cellular response is abrogated, formation of HSV-1 replication centers is retarded, and viral production is compromised. In neurons, HSV-1 replication centers fail to mature, and the DNA damage response is not initiated. These data suggest that the failure of neurons to mount a DNA damage response to HSV-1 may contribute to the establishment of latency.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
