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Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25
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Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25
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Journal Article
Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25
2012
Overview
How IL-17 signaling is regulated remains poorly understood. Dong and colleagues identify the ubiquitin-specific protease USP25 as a negative regulator of IL-17-mediated signaling and inflammation.
Interleukin 17 (IL-17) is important in infection and autoimmunity; how it signals remains poorly understood. In this study, we identified the ubiquitin-specific protease USP25 as a negative regulator of IL-17-mediated signaling and inflammation. Overexpression of USP25 inhibited IL-17-triggered signaling, whereas USP25 deficiency resulted in more phosphorylation of the inhibitor IκBα and kinase Jnk and higher expression of chemokines and cytokines, as well as a prolonged half-life for chemokine CXCL1–encoding mRNA after treatment with IL-17. Consistent with that,
Usp25
−/−
mice showed greater sensitivity to IL-17-dependent inflammation and autoimmunity
in vivo
. Mechanistically, stimulation with IL-17 induced the association of USP25 with the adaptors TRAF5 and TRAF6, and USP25 induced removal of Lys63-linked ubiquitination in TRAF5 and TRAF6 mediated by the adaptor Act1. Thus, our results demonstrate that USP25 is a deubiquitinating enzyme (DUB) that negatively regulates IL-17-triggered signaling.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Adaptor Proteins, Signal Transducing - genetics
/ Adaptor Proteins, Signal Transducing - immunology
/ Analysis
/ Animals
/ Chemokine CXCL1 - immunology
/ Gene Expression Regulation - immunology
/ I-kappa B Kinase - immunology
/ MAP Kinase Kinase 4 - genetics
/ MAP Kinase Kinase 4 - immunology
/ Mice
/ Signal Transduction - genetics
/ Signal Transduction - immunology
/ TNF Receptor-Associated Factor 5 - genetics
/ TNF Receptor-Associated Factor 5 - immunology
/ TNF Receptor-Associated Factor 6 - genetics
/ TNF Receptor-Associated Factor 6 - immunology
/ Ubiquitin Thiolesterase - deficiency
/ Ubiquitin Thiolesterase - genetics
