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Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation
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Journal Article
Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation
2018
Overview
Macrophage migration inhibitory factor (MIF) exerts multiple effects on immune cells, as well as having functions outside the immune system. MIF can promote inflammation through the induction of other cytokines, including TNF, IL-6, and IL-1 family cytokines. Here, we show that inhibition of MIF regulates the release of IL-1α, IL-1β, and IL-18, not by affecting transcription or translation of these cytokines, but via activation of the NLRP3 inflammasome. MIF is required for the interaction between NLRP3 and the intermediate filament protein vimentin, which is critical for NLRP3 activation. Further, we demonstrate that MIF interacts with NLRP3, indicating a role for MIF in inflammasome activation independent of its role as a cytokine. These data advance our understanding of how MIF regulates inflammation and identify it as a factor critical for NLRP3 inflammasome activation.
MIF is a cytokine best known for its modulatory effect on expression of proinflammatory cytokines. Here the authors show that MIF facilitates the NLRP3–vimentin interaction, resulting in Nlrp3 inflammasome activation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/21
/ 14/19
/ 14/33
/ 38/77
/ 631/80
/ 64/60
/ 96/63
/ Animals
/ Female
/ Humanities and Social Sciences
/ Humans
/ Intermediate Filament Proteins - metabolism
/ Macrophage migration inhibitory factor
/ Macrophage Migration-Inhibitory Factors - genetics
/ Macrophage Migration-Inhibitory Factors - metabolism
/ Male
/ NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
/ Proteins
/ Science
/ Vimentin
