Journal Article

Fulminant type 1 diabetes mellitus associated with Coxsackievirus type B1 infection during pregnancy: a case report

Hori, Yoshikazu, Ota, Takayuki, Yoshimatu, Hiroaki, Hayakawa, Kana, Fujimoto, Tokuzo, Nakano, Yoshio, Yamanishi, Kazuki, Hayakawa, Takahiro, Yamanishi, Hirofumi

2019

Overview

Background Fulminant type 1 diabetes is characterized by an intrinsic insulin deficiency resulting from the severe destruction of pancreatic β cells and it rapidly leads to ketoacidosis. However, the association between fulminant type 1 diabetes in pregnancy and specific viral infections has not been reported. Case presentation The patient in this study was a 31-year-old Japanese woman, and at 30 weeks of pregnancy she was admitted with marked fatigue. Fetal bradycardia was noted, and the child was delivered by emergency cesarean section but was stillborn. The maternal blood sugar level was high (427 mg/dL), but the glycated hemoglobin value was 6.2%; therefore, fulminant type 1 diabetes was suspected. Serum antibody testing confirmed a Coxsackievirus B1 infection. The patient in this case had fulminant type 1 diabetes in pregnancy associated with Coxsackievirus B1. Conclusion This case highlights that fulminant type 1 diabetes in pregnancy may be associated with Coxsackievirus B1 infection.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Antibodies / Antigens / Antiviral agents / Antiviral antibody / Antiviral drugs / Blood glucose / Blood Glucose - metabolism / Blood serum / Bradycardia / Case Report / Case reports / Case studies / Cesarean section / Coxsackievirus B1 / Coxsackievirus infections / Coxsackievirus Infections - complications / Coxsackievirus Infections - virology / Cytomegalovirus / Development and progression / Diabetes / Diabetes mellitus / Diabetes Mellitus, Type 1 - blood / Diabetes Mellitus, Type 1 - complications / Diabetes, Gestational - blood / Diabetic ketoacidosis / Diabetic Ketoacidosis - etiology / Enterovirus B, Human / Family Medicine / Female / Fulminant type 1 diabetes mellitus / General Practice / Glucose / Glycated Hemoglobin A - metabolism / Glycosylated hemoglobin / Hemoglobin / Hemoglobins / Herpes viruses / Humans / Immunoglobulins / Infection / Infections / Insulin / Insulin aspart / Internal Medicine / Laboratories / Medical research / Medicine / Medicine & Public Health / Pancreatic beta cells / Peptides / Pregnancy / Pregnant women / Primary Care Medicine / Proteins / Public Health / Risk factors / Surgical Oncology / Type 1 diabetes / Type 2 diabetes / Urine / Viral infections / Virus diseases / Vital signs / Women