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Towards a biomarker panel for the assessment of AKI in children receiving intensive care
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Towards a biomarker panel for the assessment of AKI in children receiving intensive care
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Journal Article
Towards a biomarker panel for the assessment of AKI in children receiving intensive care
2015
Overview
Background
Critically ill children and neonates are at high risk of developing acute kidney injury (AKI). AKI is associated with short- and long-term renal impairment and increased mortality. Current methods of diagnosing AKI rely on measurements of serum creatinine, which is a late and insensitive marker. Few studies to date have assessed AKI biomarkers in a heterogeneous patient cohort.
Methods
We conducted a prospective feasibility study in a paediatric intensive care setting over a 6-month period to describe the relationship between AKI (defined according to pRIFLE criteria) and new AKI biomarkers.
Results
In total, 49 patients between the ages of 16 days and 15 years were recruited for measurement of plasma cystatin C (Cys-C) and neutrophil gelatinase-associated lipocalin (pNGAL) concentrations, as well as for urinary kidney injury molecule-1 (KIM-1) and urinary NGAL (uNGAL) concentrations. Almost one-half (49 %) of the patient cohort experienced an AKI episode, and Cys-C and pNGAL were the strongest candidates for the detection of AKI. Our data suggest that the widely used estimated baseline creatinine clearance value of 120 mL/min/1.73 m
2
underestimates actual baseline function in patients admitted to paediatric intensive care units.
Conclusions
This investigation demonstrates the feasibility of new AKI biomarker testing in a mixed patient cohort and provides novel biomarker profiling for further evaluation.
Publisher
Springer Berlin Heidelberg,Springer,Springer Nature B.V
Subject
/ Acute Kidney Injury - diagnosis
/ Acute Kidney Injury - epidemiology
/ Acute Kidney Injury - metabolism
/ Child
/ Consent
/ Female
/ Hepatitis A Virus Cellular Receptor 1
/ Humans
/ Infant
/ Intensive Care Units, Pediatric
/ Male
/ Medicine
/ Membrane Glycoproteins - urine
/ Original
/ Patients
/ Proto-Oncogene Proteins - blood
/ Sepsis
/ United Kingdom - epidemiology
/ Urology
