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Journal Article
On the road to reading the RNA-interference code
2009
Overview
The finding that sequence-specific gene silencing occurs in response to the presence of double-stranded RNAs has had an enormous impact on biology, uncovering an unsuspected level of regulation of gene expression. This process, known as RNA interference (RNAi) or RNA silencing, involves small non-coding RNAs, which associate with nuclease-containing regulatory complexes and then pair with complementary messenger RNA targets, thereby preventing the expression of these mRNAs. Remarkable progress has been made towards understanding the underlying mechanisms of RNAi, raising the prospect of deciphering the 'RNAi code' that, like transcription factors, allows the fine-tuning and networking of complex suites of gene activity, thereby specifying cellular physiology and development.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Cellular signal transduction
/ Changes
/ Humanities and Social Sciences
/ Humans
/ Proteins
/ RNA
/ RNA Interference - physiology
/ RNA, Double-Stranded - biosynthesis
/ RNA, Double-Stranded - genetics
/ RNA, Double-Stranded - metabolism
/ RNA, Small Interfering - biosynthesis
/ RNA, Small Interfering - genetics
/ RNA, Small Interfering - metabolism
/ RNA, Untranslated - biosynthesis
/ RNA, Untranslated - genetics
/ RNA, Untranslated - metabolism
/ RNA-Induced Silencing Complex - metabolism
/ Science
/ Studies
