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A new method for treating fecal incontinence by implanting stem cells derived from human adipose tissue: preliminary findings of a randomized double-blind clinical trial
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A new method for treating fecal incontinence by implanting stem cells derived from human adipose tissue: preliminary findings of a randomized double-blind clinical trial
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A new method for treating fecal incontinence by implanting stem cells derived from human adipose tissue: preliminary findings of a randomized double-blind clinical trial
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Journal Article
A new method for treating fecal incontinence by implanting stem cells derived from human adipose tissue: preliminary findings of a randomized double-blind clinical trial
2017
Overview
Background
Anal sphincter defects are a major cause of fecal incontinence causing negative effects on daily life, social interactions, and mental health. Because human adipose-derived stromal/stem cells (hADSCs) are easier and safer to access, secrete high levels of growth factor, and have the potential to differentiate into muscle cells, we investigated the ability of hADSCs to improve anal sphincter incontinence.
Methods
The present randomized double-blind clinical trial was performed on patients with sphincter defects. They were categorized into a cell group (
n
= 9) and a control group (
n
= 9). Either 6 × 10
6
hADSCs per 3 ml suspended in phosphate buffer saline (treatment) or 3 ml phosphate buffer saline (placebo) was injected. Two months after surgery, the Wexner score, endorectal sonography, and electromyography (EMG) results were recorded.
Results
Comparing Wexner scores in the cell group and the control group showed no significant difference. In our EMG and endorectal sonography analysis using ImageJ/Fiji 1.46 software, the ratio of the area occupied by the muscle to total area of the lesion showed a 7.91% increase in the cell group compared with the control group.
Conclusion
The results of the current study show that injection of hADSCs during repair surgery for fecal incontinence may cause replacement of fibrous tissue, which acts as a mechanical support to muscle tissue with contractile function. This is a key point in treatment of fecal incontinence especially in the long term and may be a major step forward.
Trial registration
Iranian Registry of Clinical Trials
IRCT2016022826316N2
. Retrospectively registered 7 May 2016.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Adult
/ Aged
/ Anal Canal - diagnostic imaging
/ Anal Canal - physiopathology
/ Biomedical and Life Sciences
/ Biomedical Engineering and Bioengineering
/ Body fat
/ Fecal Incontinence - diagnostic imaging
/ Fecal Incontinence - physiopathology
/ Fecal Incontinence - surgery
/ Fecal Incontinence - therapy
/ Female
/ Human
/ Humans
/ Male
/ Regenerative Medicine/Tissue Engineering
/ Sphincterotomy, Transduodenal - methods
