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Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS
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Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS
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Journal Article
Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS
2005
Overview
Calorie restriction extends life span in organisms ranging from yeast to mammals. Here, we report that calorie restriction for either 3 or 12 months induced endothelial nitric oxide synthase (eNOS) expression and 3',5'-cyclic guanosine monophosphate formation in various tissues of male mice. This was accompanied by mitochondrial biogenesis, with increased oxygen consumption and adenosine triphosphate production, and an enhanced expression of sirtuin 1. These effects were strongly attenuated in eNOS null-mutant mice. Thus, nitric oxide plays a fundamental role in the processes induced by calorie restriction and may be involved in the extension of life span in mammals.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Analysis
/ Animals
/ ATP
/ Biological and medical sciences
/ Calories
/ DNA, Mitochondrial - metabolism
/ Female
/ Fundamental and applied biological sciences. Psychology
/ GTP Phosphohydrolases - biosynthesis
/ Male
/ Males
/ Mammals
/ Mice
/ Nitric Oxide Synthase - biosynthesis
/ Nitric Oxide Synthase - genetics
/ Nitric Oxide Synthase Type II
/ Nitric Oxide Synthase Type III
/ Obsessive compulsive disorder
/ Tissues
/ Vertebrates: anatomy and physiology, studies on body, several organs or systems
/ Yeast
/ Yeasts
