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HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection

by Martin, Maureen P. , Alexander, Graeme J. , Astemborski, Jacquie , Cramp, Matthew E. , Gao, Xiaojiang , O'Brien, Stephen J. , Cox, Steven , William M. C. Rosenberg , Thomas, David L. , Little, Ann-Margeret , Cheng, Jie , Khakoo, Salim I. , Thio, Chloe L. , Brooks, Collin R. , Carrington, Mary , Hilgartner, Margaret , Goedert, James J. , Vlahov, David

in Adolescent / Adult / African Americans / African Americans - genetics / Alleles / Antigens / Biological and medical sciences / Blood Transfusion / Cells / Child / Cohort Studies / Drug Use / European Continental Ancestry Group - genetics / Female / Genes / Genetic aspects / Genotypes / Hepacivirus - immunology / Hepacivirus - physiology / Hepatitis / Hepatitis C / Hepatitis C - genetics / Hepatitis C - immunology / Hepatitis C - transmission / Hepatitis C - virology / Hepatitis C virus / HLA antigens / HLA C antigens / HLA-C Antigens - genetics / HLA-C Antigens - immunology / HLA-C Antigens - metabolism / Homozygote / Human viral diseases / Humans / Immune response / Immune system / Infections / Infectious diseases / Killer Cells, Natural - immunology / Ligands / Male / Medical sciences / Natural killer cells / Physiological aspects / Protective effects / Receptors / Receptors, Immunologic - genetics / Receptors, Immunologic - metabolism / Receptors, KIR / Receptors, KIR2DL1 / Receptors, KIR2DL3 / Regression Analysis / Viral diseases / Viral hepatitis / Viruses / Whites

2004

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HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection

2004

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2004

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Journal Article

HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection

Martin, Maureen P.,

Alexander, Graeme J.,

Astemborski, Jacquie,

Cramp, Matthew E.,

Gao, Xiaojiang,

O'Brien, Stephen J.,

Cox, Steven,

William M. C. Rosenberg,

Thomas, David L.,

Little, Ann-Margeret,

Cheng, Jie,

Khakoo, Salim I.,

Thio, Chloe L.,

Brooks, Collin R.,

Carrington, Mary,

Hilgartner, Margaret,

Goedert, James J.,

Vlahov, David

2004

Overview

Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

Adolescent

/ Adult

/ African Americans

/ African Americans - genetics

/ Alleles

/ Antigens

/ Biological and medical sciences