Asset Details
Do you wish to reserve the book?
Activation of Central Melanocortin Pathways by Fenfluramine
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Activation of Central Melanocortin Pathways by Fenfluramine
Do you wish to request the book?
Activation of Central Melanocortin Pathways by Fenfluramine
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Activation of Central Melanocortin Pathways by Fenfluramine
2002
Overview
D-fenfluramine (d-FEN) was once widely prescribed and was among the most effective weight loss drugs, but was withdrawn from clinical use because of reports of cardiac complications in a subset of patients. Discerning the neurobiology underlying the anorexic action of d-FEN may facilitate the development of new drugs to prevent and treat obesity. Through a combination of functional neuroanatomy, feeding, and electrophysiology studies in rodents, we show that d-FEN-induced anorexia requires activation of central nervous system melanocortin pathways. These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective anti-obesity treatments.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Anatomy
/ Animals
/ Appetite Depressants - pharmacology
/ Arcuate Nucleus of Hypothalamus - drug effects
/ Arcuate Nucleus of Hypothalamus - metabolism
/ Biological and medical sciences
/ Brain
/ Central nervous system depressants
/ Dosage
/ Energy
/ Feeding Behavior - drug effects
/ General and cellular metabolism. Vitamins
/ Male
/ Melanocyte-Stimulating Hormones - pharmacology
/ Mice
/ Neurons
/ Obesity
/ Paraventricular Hypothalamic Nucleus - drug effects
/ Paraventricular Hypothalamic Nucleus - metabolism
/ Pharmacology. Drug treatments
/ Pro-Opiomelanocortin - metabolism
/ Rats
/ Receptor, Melanocortin, Type 3
/ Receptor, Melanocortin, Type 4
/ Receptors, Corticotropin - metabolism
/ Receptors, Serotonin - metabolism
