Journal Article

The genome of the model beetle and pest Tribolium castaneum

HUMAN GENOME SEQUENCING CENTER HOUSTON USA ; Partenaires IRSTEA ; Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Johann-Friedrich Blumenbach Institut für Zoologie und Anthropologie ; Georg-August-University of Göttingen = Georg-August-Universität Göttingen, Denell, R, Kansas State University, Brown, Susan, E, Weinstock, George Matthew, Biologie des écosystèmes aquatiques (UR BELY) ; Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), Chaumot, Arnaud, Gibbs, R, Richards, Stephen, Beeman, R, Bucher, G, UNITED STATES DEPARTMENT OF AGRICULTURE KANSAS USA ; Partenaires IRSTEA ; Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)

2008

Overview

Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to interact with a diverse chemical environment, as shown by large expansions in odorant and gustatory receptors, as well as P450 and other detoxification enzymes. Development in Tribolium is more representative of other insects than is Drosophila, a fact reflected in gene content and function. For example, Tribolium has retained more ancestral genes involved in cellcell communication than Drosophila, some being expressed in the growth zone crucial for axial elongation in short-germ development. Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.

• Publisher: Nature Publishing Group,CCSD,Nature Publishing Group UK,Nature Publishing
• Subject: Animals / Base Composition / Biological and medical sciences / Body Patterning / Body Patterning - genetics / Chemicals / Classical genetics, quantitative genetics, hybrids / classification / Cytochrome P-450 Enzyme System / Cytochrome P-450 Enzyme System - genetics / DNA sequencing / DNA Transposable Elements / DNA Transposable Elements - genetics / embryology / Environmental Sciences / Evolutionary biology / Fecundity / Flour beetles / Fundamental and applied biological sciences. Psychology / Gene expression / Genes / Genes, Insect / Genes, Insect - genetics / Genetic aspects / Genetics / Genetics of eukaryotes. Biological and molecular evolution / genome / Genome, Insect / Genome, Insect - genetics / Genomics / Growth and Development / Growth and Development - genetics / Humanities and Social Sciences / Humans / insect genetics / Insecticides / Insecticides - pharmacology / Insects / Invertebrata / Methods / molecular sequence data / Mosquitoes / multidisciplinary / Mutagens / Neurotransmitter Agents / Neurotransmitter Agents - genetics / nucleotide sequences / Nucleotide sequencing / Oogenesis / Oogenesis - genetics / pharmacology / Phylogeny / Physiological aspects / physiology / Proteome / Proteome - genetics / Receptors, G-Protein-Coupled / Receptors, G-Protein-Coupled - genetics / Receptors, Odorant / Receptors, Odorant - genetics / Repetitive Sequences, Nucleic Acid / Repetitive Sequences, Nucleic Acid - genetics / RNA Interference / RNA polymerase / Science / Science (multidisciplinary) / Taste / Taste - genetics / Telomere / Telomere - genetics / Tribolium / Tribolium - classification / Tribolium - embryology / Tribolium - genetics / Tribolium - physiology / Tribolium castaneum / Tribolium/classification/embryology/genetics/physiology / Vision, Ocular / Vision, Ocular - genetics / Vision/genetics
• ISBN: 9780002552080, 0002552086