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Editorial: Nutrition as a pharmacological approach to metabolic disorders and ageing
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Editorial: Nutrition as a pharmacological approach to metabolic disorders and ageing
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Journal Article
Editorial: Nutrition as a pharmacological approach to metabolic disorders and ageing
2026
Overview
[...]long-term obesity has been associated with the expression of molecular ageing signatures during young adulthood in both females and males, reinforcing the view that obesity may constitute a state of accelerated biological ageing (Correa-Burrows et al., 2025). In this context, the chronic consumption of a Western diet rich in processed foods, sugars, and unhealthy fats promotes chronic inflammation in multiple organs (Clemente-Suárez et al., 2023), driving adipose tissue expansion and dysfunction, factors that The Lancet Commission identified as key determinants of the clinical manifestations of obesity (Rubino et al., 2025). (2025)show that ginger supplementation, whose antioxidant activity derives largely from its phenolic compounds, counteracts age-related oxidative stress in the mouse liver, restoring antioxidant capacity in a dose- and ageing-dependent manner. [...]targeting senescence has emerged as a promising strategy to counteract these processes and improve metabolic health (Childs et al., 2015;Zumerle et al., 2024).
