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Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments

by Crouch, Nichola , Romaniuk, Liana , Waiter, Gordon D. , Whalley, Heather C. , Jagpal, Baljit , Deary, Ian J. , Pattie, Alison , Munafò, Marcus R. , Lawrie, Stephen M. , Buchan, Gordon , MacLennan, Beverly , Adams, Mark J. , Reynolds, Rebecca M. , Murphy, Lee , McIntosh, Andrew M. , Sandu, Anca-Larisa , Priba, Lucasz , MacIntyre, Donald J. , Hafferty, Jonathan D. , Younie, Dawn , McNeil, Christopher J. , Habota, Tina , Seckl, Jonathan R. , Haley, Christopher S. , Milburn, Keith , Porteous, David J. , Murray, Alison D. , Coupar, Tessa , Macfarlane, Jennifer A. , Valentine, Ruth , Campbell, Archie I. , Elliot, Rebecca , Steele, J. Douglas , Stirling, Mairi , Hawkins, Emma L. , Hirose, Yoriko , Harris, Mathew A. , Evans, Kathryn L. , Penton-Voak, Ian S. , Wardlaw, Joanna M.

in Biomarkers / Funding / Medical imaging / Medical research / Mental depression / Neuroimaging / NMR / Nuclear magnetic resonance / Peer review / Population / Questionnaires / Resilience (Psychology) / Studies / Supervision / Writing

2019

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Journal Article

Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments

Crouch, Nichola,

Romaniuk, Liana,

Waiter, Gordon D.,

Whalley, Heather C.,

Jagpal, Baljit,

Deary, Ian J.,

Pattie, Alison,

Munafò, Marcus R.,

Lawrie, Stephen M.,

Buchan, Gordon,

MacLennan, Beverly,

Adams, Mark J.,

Reynolds, Rebecca M.,

Murphy, Lee,

McIntosh, Andrew M.,

Sandu, Anca-Larisa,

Priba, Lucasz,

MacIntyre, Donald J.,

Hafferty, Jonathan D.,

Younie, Dawn,

McNeil, Christopher J.,

Habota, Tina,

Seckl, Jonathan R.,

Haley, Christopher S.,

Milburn, Keith,

Porteous, David J.,

Murray, Alison D.,

Coupar, Tessa,

Macfarlane, Jennifer A.,

Valentine, Ruth,

Campbell, Archie I.,

Elliot, Rebecca,

Steele, J. Douglas,

Stirling, Mairi,

Hawkins, Emma L.,

Hirose, Yoriko,

Harris, Mathew A.,

Evans, Kathryn L.,

Penton-Voak, Ian S.,

Wardlaw, Joanna M.

2019

Overview

STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at the GS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures of depression and resilience. Similarly, routine NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.

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Wellcome Trust Limited

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/ Funding

/ NMR