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The Genetics of Dyslipidemia — When Less Is More
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Journal Article
The Genetics of Dyslipidemia — When Less Is More
2016
Overview
An elevated plasma level of low-density lipoprotein (LDL) cholesterol is a major risk factor for coronary heart disease. Whether an elevated plasma triglyceride level and a reduced level of high-density lipoprotein (HDL) cholesterol also carry an increased risk of coronary heart disease has remained a contentious issue.
1
Two groups of investigators now describe in the
Journal
important genetic evidence showing a causal role of plasma triglycerides in coronary heart disease. Stitziel and colleagues
2
tested 54,003 coding-sequence variants covering 13,715 human genes in more than 72,000 patients with coronary artery disease and 120,000 controls. Dewey and colleagues
3
sequenced the exons of . . .
Publisher
Massachusetts Medical Society
Subject
