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Effect of an experimental pregabalin gel on dental sensitivity and color change after bleaching with 35% hydrogen peroxide: a randomized clinical trial
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Effect of an experimental pregabalin gel on dental sensitivity and color change after bleaching with 35% hydrogen peroxide: a randomized clinical trial
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Journal Article
Effect of an experimental pregabalin gel on dental sensitivity and color change after bleaching with 35% hydrogen peroxide: a randomized clinical trial
2025
Overview
Objective
This clinical study evaluated an experimental pregabalin (PG) gel in reducing dental sensitivity (DS) and color change after dental bleaching.
Materials and methods
Seventy-five volunteers were selected and randomized into three groups: GPG (10% pregabalin gel), GKF (5% potassium nitrate and 2% sodium fluoride), and GP (placebo gel). Prior to the bleaching treatment, GPG and GKF received applications of the respective desensitizing gels for 10 min. The GP group received an application of placebo gel, similar to the other groups. The bleaching was performed with 35% hydrogen peroxide in 3 sessions, with a 7-day interval between sessions. Post-bleaching DS was assessed using the visual analog scale (VAS) over 21 days of follow-up. Color Assessment (ΔE00, ΔWID, and ΔEab) and luminosity (L) were measured at baseline (T0) and 7 days after the third session (T1). Friedman, Kruskal-Wallis, one-way ANOVA, and Tukey tests were used, with α = 5%.
Results
Intergroup analysis showed that on the 1st, 8th, and 15th days, DS was higher for GP (
p
< 0.006;
p
= 0.004;
p
< 0.001) and did not differ between GKF and GPG (
p
= 0.203;
p
= 0.178;
p
= 0.09). In the intragroup analysis, GP showed a significant increase in DS on the 15th day (
p
< 0.001).
Conclusions
The experimental 10% pregabalin gel reduced dental sensitivity and did not interfere with bleaching results.
Clinical significance
The topical application of 10% pregabalin gels and NKF was effective in reducing tooth sensitivity 24 hoursafter whitening with 35% hydrogen peroxide.
Trial registration
ClinicalTrials.gov trial registry with the identifier NCT06180707.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Color
/ Dentin Sensitivity - chemically induced
/ Dentin Sensitivity - drug therapy
/ Dentin Sensitivity - prevention & control
/ Female
/ Gels
/ Humans
/ Hydrogen Peroxide - adverse effects
/ Male
/ Medicine
/ Placebos
/ Pregabalin - administration & dosage
/ Pregabalin - therapeutic use
/ Tooth Bleaching - adverse effects
