Journal Article

Photothermal therapy of tuberculosis using targeting pre-activated macrophage membrane-coated nanoparticles

Feng, Yi, Zhang, Yunlong, Gao, Qiuxia, Zheng, Judun, Wang, Wei, Wang, Dong, He, Lingjie, Yan, Dingyuan, Wu, Yunxia, Zhao, Lu, Li, Xiaoxue, Wang, Jiamei, Li, Bin, Wang, Huanhuan, Shu, Bowen, Yan, Yan, Zhang, Jie, Pan, Mingliang, Liao, Yuhui, Tang, Ben Zhong

2024

Overview

Conventional antibiotics used for treating tuberculosis (TB) suffer from drug resistance and multiple complications. Here we propose a lesion–pathogen dual-targeting strategy for the management of TB by coating Mycobacterium -stimulated macrophage membranes onto polymeric cores encapsulated with an aggregation-induced emission photothermal agent that is excitable with a 1,064 nm laser. The coated nanoparticles carry specific receptors for Mycobacterium tuberculosis , which enables them to target tuberculous granulomas and internal M. tuberculosis simultaneously. In a mouse model of TB, intravenously injected nanoparticles image individual granulomas in situ in the lungs via signal emission in the near-infrared region IIb, with an imaging resolution much higher than that of clinical computed tomography. With 1,064 nm laser irradiation from outside the thoracic cavity, the photothermal effect generated by these nanoparticles eradicates the targeted M. tuberculosis and alleviates pathological damage and excessive inflammation in the lungs, resulting in a better therapeutic efficacy compared with a combination of first-line antibiotics. This precise photothermal modality that uses dual-targeted imaging in the near-infrared region IIb demonstrates a theranostic strategy for TB management. Tuberculosis is a major global health issue. Here the authors report Mycobacterium -pre-activated macrophage membrane-coated photothermal nanoparticles for targeted tuberculous granuloma and pathogen dual imaging and antibacterial photothermal therapy.

• Publisher: Nature Publishing Group UK,Nature Publishing Group
• Subject: 140/125 / 140/131 / 631/61/350/354 / 631/61/54/152 / Antibiotics / Chemistry and Materials Science / Coatings / Computed tomography / Drug resistance / Emission / Emissions / Global health / Granuloma / Granulomas / I.R. radiation / Image resolution / Irradiation / Laser radiation / Lungs / Macrophages / Materials Science / Membranes / Mycobacterium / Nanoparticles / Nanotechnology / Nanotechnology and Microengineering / Near infrared radiation / Pathogens / Public health / Thorax / Tuberculosis