Asset Details
Do you wish to reserve the book?
Stabilized ascorbic acid derivatives in microneedle systems: a targeted approach for dermatological anti-aging and pigmentation correction
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Stabilized ascorbic acid derivatives in microneedle systems: a targeted approach for dermatological anti-aging and pigmentation correction
Do you wish to request the book?
Stabilized ascorbic acid derivatives in microneedle systems: a targeted approach for dermatological anti-aging and pigmentation correction
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Stabilized ascorbic acid derivatives in microneedle systems: a targeted approach for dermatological anti-aging and pigmentation correction
2026
Overview
Background
Skin aging and hyperpigmentation disorders, primarily driven by oxidative stress, pose major dermatological challenges. Ascorbic acid plays a crucial role in collagen synthesis and modulation of melanogenesis; however, its clinical utility is restricted due to chemical instability and poor transdermal permeability.
Objective
This study aimed to develop and characterize dissolving microneedles (MNs) composed of polyvinyl alcohol (PVA) and glycerol for enhanced dermal delivery of stabilized ascorbic acid derivatives—ascorbyl palmitate (AP) and ascorbyl glucoside (AG).
Methods
MNs (11 × 11 array, 600 μm height) were fabricated via solvent casting using varying concentrations of PVA. The optimized formulation (12% PVA) was evaluated for mechanical strength, drug loading, insertion depth, and physicochemical stability using tensile testing, microscopy, FTIR spectroscopy, and thermal analysis. Antioxidant activity and in vitro drug release profiles were also assessed.
Results and Discussion
The optimized MNs exhibited robust mechanical properties (tensile strength: 10.17 ± 1.44 MPa) and uniform drug loading (AP: 50 ± 2.14 µg/patch; AG: 70 ± 1.24 µg/patch). Penetration studies confirmed successful skin insertion to approximately 508 μm depth with maintained structural integrity. FTIR and thermal analyses revealed amorphous solid dispersion without chemical interactions. Both AP-MNs and AG-MNs retained antioxidant activity post-encapsulation (IC₅₀: 25.4 ± 2.9 µg/mL and 62.1 ± 3.7 µg/mL, respectively) and demonstrated sustained release over 24 h (98 ± 2.41% for AP-MNs; 95 ± 1.32% for AG-MNs).
Conclusion
PVA-glycerol dissolving microneedles effectively delivered ascorbic acid derivatives transdermally, maintaining stability and antioxidant function. These MN systems present a promising, minimally invasive platform for anti-aging and hyperpigmentation therapies warranting biological validation to confirm therapeutic efficacy.
Publisher
Springer International Publishing,Springer Nature B.V,SpringerOpen
Subject
