Asset Details
Do you wish to reserve the book?
In Vivo Risk Evaluation of Carbon-Coated Iron Carbide Nanoparticles Based on Short- and Long-Term Exposure Scenarios
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
In Vivo Risk Evaluation of Carbon-Coated Iron Carbide Nanoparticles Based on Short- and Long-Term Exposure Scenarios
Do you wish to request the book?
In Vivo Risk Evaluation of Carbon-Coated Iron Carbide Nanoparticles Based on Short- and Long-Term Exposure Scenarios
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
In Vivo Risk Evaluation of Carbon-Coated Iron Carbide Nanoparticles Based on Short- and Long-Term Exposure Scenarios
2016
Overview
While carbon-encapsulated iron carbide nanoparticles exhibit strong magnetic properties appealing for biomedical applications, potential side effects of such materials remain comparatively poorly understood. Here, we assess the effects of iron-based nanoparticles in an in vivo long-term study in mice with observation windows between 1 week and 1 year.
Functionalized (PEG or IgG) carbon-encapsulated platinum-spiked iron carbide nanoparticles were injected intravenously in mice (single or repeated dose administration).
One week after administration, magnetic nanoparticles were predominantly localized in organs of the reticuloendothelial system, particularly the lung and liver. After 1 year, particles were still present in these organs, however, without any evident tissue alterations, such as inflammation, fibrosis, necrosis or carcinogenesis. Importantly, reticuloendothelial system organs presented with normal function.
This long-term exposure study shows high in vivo compatibility of intravenously applied carbon-encapsulated iron nanoparticles suggesting continuing investigations on such materials for biomedical applications.
Publisher
Future Medicine Ltd
Subject
/ Carbon
/ Carbon - administration & dosage
/ Carbon Compounds, Inorganic - administration & dosage
/ Carbon Compounds, Inorganic - adverse effects
/ Carbon Compounds, Inorganic - chemistry
/ Carbon Compounds, Inorganic - pharmacokinetics
/ Coated Materials, Biocompatible - administration & dosage
/ Coated Materials, Biocompatible - adverse effects
/ Coated Materials, Biocompatible - chemistry
/ Drug Carriers - administration & dosage
/ Drug Carriers - adverse effects
/ Drug Carriers - pharmacokinetics
/ Female
/ Iron Compounds - administration & dosage
/ Iron Compounds - adverse effects
/ Iron Compounds - pharmacokinetics
/ Liver
/ Male
/ Mice
/ Nanoparticles - administration & dosage
