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Cytomegalovirus Ileitis in a Patient With Post-severe Trauma: A Case Report
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Cytomegalovirus Ileitis in a Patient With Post-severe Trauma: A Case Report
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Journal Article
Cytomegalovirus Ileitis in a Patient With Post-severe Trauma: A Case Report
2024
Overview
The mortality rate for alimentary tract hemorrhage remains high due to a variety of contributing factors. In this report, we present a case of post-severe trauma patient with life-threatening gastrointestinal bleeding caused by cytomegalovirus (CMV)-induced damage to the terminal ileum.
A 76-year-old female with a history of hypertension and gastrointestinal bleeding developed CMV ileitis post-severe trauma. Despite negative CMV IgM antibodies, PCR testing confirmed CMV infection in the biopsy tissue. Histopathological examination revealed viral inclusion bodies, with immunohistochemistry confirming CMV presence.
Intravenous ganciclovir effectively managed symptoms and halted bleeding. CMV ileitis, typically seen in immunocompromised states, may occur sporadically in immunocompetent individuals, including post-orthopedic surgery patients. The exact mechanism remains unclear, possibly related to surgical stress. Diagnosis relies on histopathology and immunohistochemistry.
Early recognition and treatment are vital for optimal outcomes, emphasizing the need for awareness among orthopedic surgeons regarding CMV as a potential cause of postoperative complications.
Publisher
International Institute of Anticancer Research
Subject
Acquired immune deficiency syndrome
/ Aged
/ AIDS
/ Antiviral Agents - therapeutic use
/ Biopsy
/ Cytomegalovirus Infections - complications
/ Cytomegalovirus Infections - diagnosis
/ Female
/ Ganciclovir - therapeutic use
/ Gastrointestinal Hemorrhage - etiology
/ Gastrointestinal Hemorrhage - virology
/ HIV
/ Human immunodeficiency virus
/ Humans
/ Patients
/ Surgery
/ Ulcers
