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Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

by Goodfellow, Michael , Rateb, Mostafa E , Wichner, Dominik , Bull, Alan T , Asenjo, Juan A , Idris, Hamidah , Houssen, Wael E , McEwan, Andrew R , Jaspars, Marcel , Ebel, Rainer

in Actinomycetales - chemistry / Actinomycetales - classification / Actinomycetales - genetics / Actinomycetes / Altitude / Antibiotics / Antiviral activity / Chile / Chromatography / Desert Climate / Desert soils / Deserts / Fermentation / Genomes / Glycosides / High altitude / High-altitude environments / HIV / HIV Integrase Inhibitors - pharmacology / HIV-1 - drug effects / HIV-1 - enzymology / Human immunodeficiency virus / Integrase / Magnetic Resonance Spectroscopy / Metabolites / Morphology / Natural products / NMR / Nuclear magnetic resonance / Pharmacy / Phylogenetics / Phylogeny / RNA, Fungal - genetics / RNA, Ribosomal, 16S - genetics / Sandy soils / Soil Microbiology / Spectrometry, Mass, Electrospray Ionization

2017

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Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

by Goodfellow, Michael , Rateb, Mostafa E , Wichner, Dominik , Bull, Alan T , Asenjo, Juan A , Idris, Hamidah , Houssen, Wael E , McEwan, Andrew R , Jaspars, Marcel , Ebel, Rainer

2017

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Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

by Goodfellow, Michael , Rateb, Mostafa E , Wichner, Dominik , Bull, Alan T , Asenjo, Juan A , Idris, Hamidah , Houssen, Wael E , McEwan, Andrew R , Jaspars, Marcel , Ebel, Rainer

2017

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Journal Article

Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

Goodfellow, Michael,

Rateb, Mostafa E,

Wichner, Dominik,

Bull, Alan T,

Asenjo, Juan A,

Idris, Hamidah,

Houssen, Wael E,

McEwan, Andrew R,

Jaspars, Marcel,

Ebel, Rainer

2017

Overview

The extremotolerant isolate H45 was one of several actinomycetes isolated from a high-altitude Atacama Desert soil collected in northwest Chile. The isolate was identified as a new Lentzea sp. using a combination of chemotaxonomic, morphological and phylogenetic properties. Large scale fermentation of the strain in two different media followed by chromatographic purification led to the isolation of six new diene and monoene glycosides named lentzeosides A-F, together with the known compound (Z)-3-hexenyl glucoside. The structures of the new compounds were confirmed by HRESIMS and NMR analyses. Compounds 1-6 displayed moderate inhibitory activity against HIV integrase.

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Publisher

Nature Publishing Group

Subject

Actinomycetales - chemistry

/ Actinomycetales - classification

/ Actinomycetales - genetics