Asset Details
Do you wish to reserve the book?
Emerging Antineoplastic Plant-Based Gold Nanoparticle Synthesis: A Mechanistic Exploration of their Anticancer Activity Toward Cervical Cancer Cells
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Emerging Antineoplastic Plant-Based Gold Nanoparticle Synthesis: A Mechanistic Exploration of their Anticancer Activity Toward Cervical Cancer Cells
Do you wish to request the book?
Emerging Antineoplastic Plant-Based Gold Nanoparticle Synthesis: A Mechanistic Exploration of their Anticancer Activity Toward Cervical Cancer Cells
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Emerging Antineoplastic Plant-Based Gold Nanoparticle Synthesis: A Mechanistic Exploration of their Anticancer Activity Toward Cervical Cancer Cells
2020
Overview
In this work, gold nanoparticles (AuNPs) were synthesised using the fresh leaves extract of
Pongamia pinnata
(PLE) and characterized using various analytical techniques such as UV–visible spectroscopy, TEM, SEM, EDX, and XRD. UV–Visible spectra showed surface plasmon resonance (SPR) peaks in the range of 520–540 nm signifying the synthesis of colloidal AuNPs stabilised by PLE. Further, we investigated the cytotoxic effects of AuNPs against human cervical cancer cell line (HeLa). MTT assay screened IC
50
value of 200 μg/mL at 24 h for AuNPs formed at varying HAuCl
4
concentration. Flow cytometry measurements using H
2
DCFDA showed that the toxicity of AuNPs was attributed to the generation of reactive oxygen species (ROS). Besides, the in vitro anticancer activities of AuNPs were studied in HeLa cells by several assays which resulted in altered cell morphology, reduced potential of wound healing, inactive mitochondria due to loss of mitochondrial membrane potential (MMP) and cell cycle arrest. AuNPs showed dose-dependent selective toxicity towards HeLa cells and were non-toxic against human embryonic kidney cell line (HEK293). The study revealed an efficient, ecofriendly and simple method for synthesis of multifunctional AuNPs using green synthetic approach with high anticancer potential for cervical cancer cell line.
Publisher
Springer US,Springer Nature B.V
Subject
